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Structure paper

TitleStructure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (beta-secretase).
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 15, Page 15-20, Year 2005
Publish dateOct 18, 2004 (structure data deposition date)
AuthorsGhosh, A.K. / Devasamudram, T. / Hong, L. / Dezutter, C. / Xu, X. / Weerasena, V. / Koelsch, G. / Bilcer, G. / Tang, J.
External linksBioorg. Med. Chem. Lett. / PubMed:15582402
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-1xs7:
Crystal Structure of a cycloamide-urethane-derived novel inhibitor bound to human brain memapsin 2 (beta-secretase).
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-MMI:
N-[(4S,5S,7R)-8-({(S)-1-[(BENZYLAMINO)OXOMETHYL]-2-METHYLPROPYL}AMINO)-5-HYDROXY-2,7-DIMETHYL-8-OXO-OCT-4-YL]-(4S,7S)-4

Source
  • homo sapiens (human)
KeywordsHYDROLASE / beta secretase / memapsin2 / BACE / ASP2 / Aspartic Protease / acid protease / Alzheimer's disease / drug design

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