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Structure paper

TitleCrystal structure of the thrombin mutant D221A/D222K: the Asp222:Arg187 ion-pair stabilizes the fast form
Journal, issue, pagesBiophys. Chem., Vol. 112, Page 253-256, Year 2004
Publish dateJul 1, 2004 (structure data deposition date)
AuthorsPineda, A.O. / Zhang, E. / Guinto, E.R. / Savvides, S.N. / Tulinsky, A. / Di Cera, E.
External linksBiophys. Chem. / PubMed:15572256
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-1twx:
Crystal structure of the thrombin mutant D221A/D222K
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / thrombin / HYDROLASE / HYDROLASE-HYDROLASE INHIBITOR COMPLEX

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