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-Structure paper
Title | The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design. |
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Journal, issue, pages | J. Am. Chem. Soc., Vol. 126, Page 15405-15411, Year 2004 |
Publish date | Jul 25, 2004 (structure data deposition date) |
![]() | Greenblatt, H.M. / Guillou, C. / Guenard, D. / Argaman, A. / Botti, S. / Badet, B. / Thal, C. / Silman, I. / Sussman, J.L. |
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Methods | X-ray diffraction |
Resolution | 2.05 - 2.4 Å |
Structure data | ![]() PDB-1w4l: ![]() PDB-1w6r: ![]() PDB-1w75: ![]() PDB-1w76: |
Chemicals | ![]() ChemComp-NAG: ![]() ChemComp-GL8: ![]() ChemComp-HOH: ![]() ChemComp-GNT: ![]() ChemComp-MG: |
Source |
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![]() | HYDROLASE / ALZHEIMER'S DISEASE / CHOLINESTERASE / GLYCOPROTEIN / GPI-ANCHOR / MUSCLE / NERVE / NEUROTRANSMITTER DEGRADATION / SERINE ESTERASE / SERINE HYDROLASE / SYNAPSE / GPI- ANCHOR |