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Structure paper

TitleNovel purine nitrile derived inhibitors of the cysteine protease cathepsin K
Journal, issue, pagesJ. Med. Chem., Vol. 47, Page 5833-5836, Year 2004
Publish dateAug 11, 2004 (structure data deposition date)
AuthorsAltmann, E. / Cowan-Jacob, S.W. / Missbach, M.
External linksJ. Med. Chem. / PubMed:15537340
MethodsX-ray diffraction
Resolution2.1 - 2.3 Å
Structure data

PDB-1u9v:
Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABE854
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-1u9w:
Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABI491
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-1u9x:
Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABJ688
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-IHE:
6-(CYCLOHEXYLAMINO)-9-[2-(4-METHYLPIPERAZIN-1-YL)-ETHYL]-9H-PURINE-2-CARBONITRILE

ChemComp-HOH:
WATER

ChemComp-IHI:
9-CYCLOPENTYL-6-[2-(3-IMIDAZOL-1-YL-PROPOXY)-PHENYLAMINO]-9H-PURINE-2-CARBONITRILE

ChemComp-IHJ:
9-CYCLOPENTYL-6-{2-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPOXY]-PHENYLAMINO}-9H-PURINE-2-CARBONITRILE

Source
  • homo sapiens (human)
KeywordsHYDROLASE / SULFHYDRYL PROTEINASE

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