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TitleRegiospecificity determinants of human heme oxygenase: differential NADPH- and ascorbate-dependent heme cleavage by the R183E mutant.
Journal, issue, pagesJ. Biol. Chem., Vol. 280, Page 2797-2806, Year 2005
Publish dateSep 26, 2004 (structure data deposition date)
AuthorsWang, J. / Lad, L. / Poulos, T.L. / Ortiz de montellano, P.R.
External linksJ. Biol. Chem. / PubMed:15525643
MethodsX-ray diffraction
Resolution2.08 - 2.2 Å
Structure data

PDB-1xk2:
NADPH- and Ascorbate-Supported Heme Oxygenase Reactions are Distinct. Regiospecificity of Heme Cleavage by the R183E Mutant
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-1xk3:
NADPH- and Ascorbate-Supported Heme Oxygenase Reactions are Distinct. Regiospecificity of Heme Cleavage by the R183E Mutant
Method: X-RAY DIFFRACTION / Resolution: 2.08 Å

Chemicals

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-HOH:
WATER

ChemComp-NO:
NITRIC OXIDE

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / heme / heme degradation / catalytic mechanism

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