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TitleStructural and mechanistic analysis of sialic acid synthase NeuB from Neisseria meningitidis in complex with Mn2+, phosphoenolpyruvate, and N-acetylmannosaminitol.
Journal, issue, pagesJ. Biol. Chem., Vol. 280, Page 3555-3563, Year 2005
Publish dateOct 26, 2004 (structure data deposition date)
AuthorsGunawan, J. / Simard, D. / Gilbert, M. / Lovering, A.L. / Wakarchuk, W.W. / Tanner, M.E. / Strynadka, N.C.
External linksJ. Biol. Chem. / PubMed:15516336
MethodsX-ray diffraction
Resolution1.9 - 2.2 Å
Structure data

PDB-1xuu:
Crystal structure of sialic acid synthase (NeuB) in complex with Mn2+ and Malate from Neisseria meningitidis
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-1xuz:
Crystal structure analysis of sialic acid synthase (NeuB)from Neisseria meningitidis, bound to Mn2+, Phosphoenolpyruvate, and N-acetyl mannosaminitol
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-MLT:
D-MALATE

ChemComp-HOH:
WATER

ChemComp-MMN:
5-DEOXY-5-{[(1S)-1-HYDROXYETHYL]AMINO}-D-GLUCITOL

ChemComp-PEP:
PHOSPHOENOLPYRUVATE

Source
  • neisseria meningitidis (bacteria)
KeywordsBIOSYNTHETIC PROTEIN / TIM barrel / Antifreeze-like domain / Domain-swapped dimer

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