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Structure paper

TitleStructural basis for coevolution of a human immunodeficiency virus type 1 nucleocapsid-p1 cleavage site with a V82A drug-resistant mutation in viral protease
Journal, issue, pagesJ. Virol., Vol. 78, Page 12446-12454, Year 2004
Publish dateJun 21, 2004 (structure data deposition date)
AuthorsPrabu-Jeyabalan, M. / Nalivaika, E.A. / King, N.M. / Schiffer, C.A.
External linksJ. Virol. / PubMed:15507631
MethodsX-ray diffraction
Resolution2 - 2.1 Å
Structure data

PDB-1tsq:
CRYSTAL STRUCTURE OF AP2V SUBSTRATE VARIANT OF NC-P1 DECAMER PEPTIDE IN COMPLEX WITH V82A/D25N HIV-1 PROTEASE MUTANT
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-1tsu:
CRYSTAL STRUCTURE OF DECAMER NCP1 SUBSTRATE PEPTIDE IN COMPLEX WITH WILD-TYPE D25N HIV-1 PROTEASE VARIANT
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

Keywordshydrolase/viral protein / CO-EVOLUTION / NUCLEOCAPDIS / SUBSTRATE RECOGNITION / HIV-1 PROTEASE / hydrolase-viral protein COMPLEX / Viral protein/hydrolase / Viral protein-hydrolase COMPLEX

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