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Structure paper

TitleA novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase.
Journal, issue, pagesJ. Biol. Chem., Vol. 279, Page 55827-55832, Year 2004
Publish dateAug 30, 2004 (structure data deposition date)
AuthorsAtwell, S. / Adams, J.M. / Badger, J. / Buchanan, M.D. / Feil, I.K. / Froning, K.J. / Gao, X. / Hendle, J. / Keegan, K. / Leon, B.C. ...Atwell, S. / Adams, J.M. / Badger, J. / Buchanan, M.D. / Feil, I.K. / Froning, K.J. / Gao, X. / Hendle, J. / Keegan, K. / Leon, B.C. / Muller-Deickmann, H.J. / Nienaber, V.L. / Noland, B.W. / Post, K. / Rajashankar, K.R. / Ramos, A. / Russell, M. / Burley, S.K. / Buchanan, S.G.
External linksJ. Biol. Chem. / PubMed:15507431
MethodsX-ray diffraction
Resolution1.57 - 2 Å
Structure data

PDB-1xba:
Crystal structure of apo syk tyrosine kinase domain
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-1xbb:
Crystal structure of the syk tyrosine kinase domain with Gleevec
Method: X-RAY DIFFRACTION / Resolution: 1.57 Å

PDB-1xbc:
Crystal structure of the syk tyrosine kinase domain with Staurosporin
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-STI:
4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE / medication, inhibitor*YM

ChemComp-STU:
STAUROSPORINE / anticancer, antifungal, antibiotic, alkaloid*YM

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / spleen typrosine kinase / active conformation / structural genomics / Structural GenomiX / Gleevec / STI-571 / Imatinib / SYK / staurosporine

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