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Structure paper

TitleStructural Basis of 5-Nitroimidazole Antibiotic Resistance: The Crystal Structure of Nima from Deinococcus Radiodurans
Journal, issue, pagesJ. Biol. Chem., Vol. 279, Page 55840-, Year 2004
Publish dateJul 17, 2004 (structure data deposition date)
AuthorsLeiros, H.-K.S. / Kozielski-Stuhrmann, S. / Kapp, U. / Terradot, L. / Leonard, G.A. / Mcsweeney, S.M.
External linksJ. Biol. Chem. / PubMed:15492014
MethodsX-ray diffraction
Resolution1.6 - 1.9 Å
Structure data

PDB-1w3o:
Crystal structure of NimA from D. radiodurans
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-1w3p:
NimA from D. radiodurans with a His71-Pyruvate residue
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-1w3q:
NimA from D. radiodurans with covalenly bound lactate
Method: X-RAY DIFFRACTION / Resolution: 1.88 Å

PDB-1w3r:
NimA from D. radiodurans with Metronidazole and Pyruvate
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-ACT:
ACETATE ION

ChemComp-PYR:
PYRUVIC ACID

ChemComp-HOH:
WATER

ChemComp-LAC:
LACTIC ACID

ChemComp-2MN:
Metronidazole / medication, antibiotic*YM

Source
  • deinococcus radiodurans (radioresistant)
KeywordsANTIBIOTIC RESISTANCE / DEINOCOCCUS RADIODURANS / 5-NITROIMIDAZOLE RESISTANCE / NIM GENE / CATALYTIC MECHANISM

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