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TitleCrystal Structure of a Eukaryotic Zn-Dependent Histone Deacetylase,Human Hdac8,Complexed with a Hydroxamic Acid Inhibitor
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 101, Page 15064-, Year 2004
Publish dateJun 25, 2004 (structure data deposition date)
AuthorsVannini, A. / Volpari, C. / Filocamo, G. / Caroli Casavola, E. / Brunetti, M. / Renzoni, D. / Chakravarty, P. / Paolini, C. / De Francesco, R. / Gallinari, P. ...Vannini, A. / Volpari, C. / Filocamo, G. / Caroli Casavola, E. / Brunetti, M. / Renzoni, D. / Chakravarty, P. / Paolini, C. / De Francesco, R. / Gallinari, P. / Steinckuhler, C. / Di Marco, S.
External linksProc. Natl. Acad. Sci. USA / PubMed:15477595
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-1w22:
Crystal structure of inhibited human HDAC8
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-K:
Unknown entry

ChemComp-NHB:
N-HYDROXY-4-(METHYL{[5-(2-PYRIDINYL)-2-THIENYL]SULFONYL}AMINO)BENZAMIDE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / HYDROXAMIC ACID / CHROMATIN / DEACETYLATION / HDAC / NUCLEAR PROTEIN / REPRESSOR

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