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TitleDesign, synthesis, biological activity and structural analysis of cyclic peptide inhibitors targeting the substrate recruitment site of cyclin-dependent kinase complexes.
Journal, issue, pagesOrg. Biomol. Chem., Vol. 2, Page 2735-2741, Year 2004
Publish dateOct 28, 2003 (structure data deposition date)
AuthorsAndrews, M.J. / McInnes, C. / Kontopidis, G. / Innes, L. / Cowan, A. / Plater, A. / Fischer, P.M.
External linksOrg. Biomol. Chem. / PubMed:15455144
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-1urc:
Cyclin A binding groove inhibitor Ace-Arg-Lys-Leu-Phe-Gly
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTRANSFERASE/INHIBITOR / TRANSFERASE-INHIBITOR COMPLEX / INHIBITOR / LIGAND EXCHANGE / DRUG DESIGN / PEPTIDOMIMETICS

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