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TitleAn Aldol Switch Discovered in Stilbene Synthases Mediates Cyclization Specificity of Type III Polyketide Synthases
Journal, issue, pagesChem. Biol., Vol. 11, Page 1179-1194, Year 2004
Publish dateJul 14, 2004 (structure data deposition date)
AuthorsAustin, M.B. / Bowman, M.E. / Ferrer, J.-L. / Schroder, J. / Noel, J.P.
External linksChem. Biol. / PubMed:15380179
MethodsX-ray diffraction
Resolution1.9 - 2.11 Å
Structure data

PDB-1u0u:
An Aldol Switch Discovered in Stilbene Synthases Mediates Cyclization Specificity of Type III Polyketide Synthases: Pine stilbene synthase structure
Method: X-RAY DIFFRACTION / Resolution: 2.11 Å

PDB-1u0v:
An Aldol Switch Discovered in Stilbene Synthases Mediates Cyclization of Specificity of Type III Polyketide Synthases: 18xCHS structure
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-1u0w:
An Aldol Switch Discovered in Stilbene Synthases Mediates Cyclization Specificity of Type III Polyketide Synthases: 18xCHS+resveratrol Structure
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-STL:
RESVERATROL

Source
  • pinus sylvestris (Scots pine)
  • medicago sativa (alfalfa)
KeywordsTRANSFERASE / PKS / type III polyketide synthase / condensing enzyme / thiolase fold / alpha-beta-alpha-beta-alpha fold / aldol switch / catalytic triad / engineered resveratrol synthase / RS / STS / CHS / chalcone synthase / stilbene synthase

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