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Structure paper

TitleStructural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics
Journal, issue, pagesNature, Vol. 432, Page 59-67, Year 2004
Publish dateJul 7, 2004 (structure data deposition date)
AuthorsXiao, T. / Takagi, J. / Coller, B.S. / Wang, J.-H. / Springer, T.A.
External linksNature / PubMed:15378069
MethodsX-ray diffraction
Resolution2.9 Å
Structure data

PDB-1tye:
Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the platelet receptor for fibrinogen
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-CAC:
CACODYLATE ION

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCELL ADHESION / crystal structure; platelet integrin alphaIIBbeta3; fibrinogen binding; allostery; therapeutic antagonism

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