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Structure paper

TitleA unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells.
Journal, issue, pagesCancer Res., Vol. 64, Page 6652-6659, Year 2004
Publish dateSep 29, 2004 (structure data deposition date)
AuthorsWood, E.R. / Truesdale, A.T. / McDonald, O.B. / Yuan, D. / Hassell, A. / Dickerson, S.H. / Ellis, B. / Pennisi, C. / Horne, E. / Lackey, K. ...Wood, E.R. / Truesdale, A.T. / McDonald, O.B. / Yuan, D. / Hassell, A. / Dickerson, S.H. / Ellis, B. / Pennisi, C. / Horne, E. / Lackey, K. / Alligood, K.J. / Rusnak, D.W. / Gilmer, T.M. / Shewchuk, L.
External linksCancer Res. / PubMed:15374980
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-1xkk:
EGFR kinase domain complexed with a quinazoline inhibitor- GW572016
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-FMM:
N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE / inhibitor*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / EGFR / epidermal growth factor receptor / kinase

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