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Structure paper

TitleStructure of an anti-DNA fab complexed with a non-DNA ligand provides insights into cross-reactivity and molecular mimicry.
Journal, issue, pagesProteins, Vol. 57, Page 269-278, Year 2004
Publish dateMay 2, 2003 (structure data deposition date)
AuthorsSchuermann, J.P. / Henzl, M.T. / Deutscher, S.L. / Tanner, J.J.
External linksProteins / PubMed:15340914
MethodsX-ray diffraction
Resolution1.75 Å
Structure data

PDB-1p7k:
Crystal structure of an anti-ssDNA antigen-binding fragment (Fab) bound to 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid (HEPES)
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-1PE:
PENTAETHYLENE GLYCOL / precipitant*YM

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / FAB / ANTIBODY / ANTI-DNA ANTIBODY / AUTOANTIBODY / LUPUS / HEPES

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