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TitleEvidence for Ligand-independent Transcriptional Activation of the Human Estrogen-related Receptor {alpha} (ERR{alpha}): CRYSTAL STRUCTURE OF ERR{alpha} LIGAND BINDING DOMAIN IN COMPLEX WITH PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR COACTIVATOR-1{alpha}
Journal, issue, pagesJ. Biol. Chem., Vol. 279, Page 49330-49337, Year 2004
Publish dateAug 30, 2004 (structure data deposition date)
AuthorsKallen, J. / Schlaeppi, J.M. / Bitsch, F. / Filipuzzi, I. / Schilb, A. / Riou, V. / Graham, A. / Strauss, A. / Geiser, M. / Fournier, B.
External linksJ. Biol. Chem. / PubMed:15337744
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-1xb7:
X-ray structure of ERRalpha LBD in complex with a PGC-1alpha peptide at 2.5A resolution
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-IOD:
IODIDE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / nuclear hormone receptor / ligand binding domain / three-layered alpha-helical sandwich / coactivator peptide / amphipathic alpha-helix

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