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Structure paper

TitleError-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase.
Journal, issue, pagesNature, Vol. 431, Page 217-221, Year 2004
Publish dateJul 23, 2004 (structure data deposition date)
AuthorsHsu, G.W. / Ober, M. / Carell, T. / Beese, L.S.
External linksNature / PubMed:15322558
MethodsX-ray diffraction
Resolution1.6 - 2.15 Å
Structure data

PDB-1u45:
8oxoguanine at the pre-insertion site of the polymerase active site
Method: X-RAY DIFFRACTION / Resolution: 2.01 Å

PDB-1u47:
cytosine-8-Oxoguanine base pair at the polymerase active site
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-1u48:
Extension of a cytosine-8-oxoguanine base pair
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-1u49:
Adenine-8oxoguanine mismatch at the polymerase active site
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

PDB-1u4b:
Extension of an adenine-8oxoguanine mismatch
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • geobacillus stearothermophilus (bacteria)
KeywordsTRANSFERASE/DNA / DNA polymerase I; DNA replication; klenow fragment; protein-DNA complex; 8oxoguanine; DNA lesion; translation replication / TRANSFERASE-DNA COMPLEX

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