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-Structure paper
Title | High-Resolution Structures of Human Aldose Reductase Holoenzyme in Complex with Stereoisomers of the Potent Inhibitor Fidarestat: Stereospecific Interaction between the Enzyme and a Cyclic Imide Type Inhibitor |
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Journal, issue, pages | J. Med. Chem., Vol. 47, Page 4530-4537, Year 2004 |
Publish date | Aug 19, 2004 (structure data deposition date) |
![]() | El-Kabbani, O. / Darmanin, C. / Oka, M. / Schulze-Briese, C. / Tomizaki, T. / Hazemann, I. / Mitschler, A. / Podjarny, A. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.3 - 1.4 Å |
Structure data | ![]() PDB-1x96: ![]() PDB-1x97: ![]() PDB-1x98: |
Chemicals | ![]() ChemComp-NAP: ![]() ChemComp-CIT: ![]() ChemComp-HOH: ![]() ChemComp-FIR: ![]() ChemComp-FIS: |
Source |
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![]() | OXIDOREDUCTASE / Eight strandard alpha/beta barrel / active site / the C-terminal end of the barrel |