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Structure paper

TitleA Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases
Journal, issue, pagesMol. Cell, Vol. 15, Page 279-286, Year 2004
Publish dateMay 18, 2004 (structure data deposition date)
AuthorsZhang, K.Y.J. / Card, G.L. / Suzuki, Y. / Artis, D.R. / Fong, D. / Gillette, S. / Hsieh, D. / Neiman, J. / West, B.L. / Zhang, C. ...Zhang, K.Y.J. / Card, G.L. / Suzuki, Y. / Artis, D.R. / Fong, D. / Gillette, S. / Hsieh, D. / Neiman, J. / West, B.L. / Zhang, C. / Milburn, M.V. / Kim, S.-H. / Schlessinger, J. / Bollag, G.
External linksMol. Cell / PubMed:15260978
MethodsX-ray diffraction
Resolution1.3 - 2.15 Å
Structure data

PDB-1t9r:
Catalytic Domain Of Human Phosphodiesterase 5A
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-1t9s:
Catalytic Domain Of Human Phosphodiesterase 5A in Complex with GMP
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-1taz:
Catalytic Domain Of Human Phosphodiesterase 1B
Method: X-RAY DIFFRACTION / Resolution: 1.77 Å

PDB-1tb5:
Catalytic Domain Of Human Phosphodiesterase 4B In Complex With AMP
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

PDB-1tb7:
Catalytic Domain Of Human Phosphodiesterase 4D In Complex With AMP
Method: X-RAY DIFFRACTION / Resolution: 1.63 Å

PDB-1tbb:
Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Rolipram
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-1tbf:
Catalytic Domain Of Human Phosphodiesterase 5A in Complex with Sildenafil
Method: X-RAY DIFFRACTION / Resolution: 1.3 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-PO4:
PHOSPHATE ION

ChemComp-CIT:
CITRIC ACID

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

ChemComp-5GP:
GUANOSINE-5'-MONOPHOSPHATE

ChemComp-AMP:
ADENOSINE MONOPHOSPHATE / AMP*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-B3P:
2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-ROL:
ROLIPRAM / antidepressant, inhibitor*YM

ChemComp-VIA:
5-{2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-1-METHYL-3-PROPYL-1H,6H,7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE

ChemComp-GOL:
GLYCEROL

Source
  • homo sapiens (human)
KeywordsHYDROLASE / PDE5A / PDE1B / PDE4B / PDE4D

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