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Structure paper

TitleStructural mechanism of the simultaneous binding of two drugs to a multidrug-binding protein
Journal, issue, pagesEmbo J., Vol. 23, Page 2923-2930, Year 2004
Publish dateAug 28, 2003 (structure data deposition date)
AuthorsSchumacher, M.A. / Miller, M.C. / Brennan, R.G.
External linksEmbo J. / PubMed:15257299
MethodsX-ray diffraction
Resolution2.89 - 2.96 Å
Structure data

PDB-1qvt:
CRYSTAL STRUCTURE OF THE MULTIDRUG BINDING TRANSCRIPTIONAL REPRESSOR QACR BOUND TO THE DRUG PROFLAVINE
Method: X-RAY DIFFRACTION / Resolution: 2.89 Å

PDB-1qvu:
Crystal structure of the multidrug binding transcriptional repressor QacR bound to two drugs: ethidium and proflavine
Method: X-RAY DIFFRACTION / Resolution: 2.96 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-PRL:
PROFLAVIN

ChemComp-HOH:
WATER

ChemComp-ET:
ETHIDIUM

Source
  • staphylococcus aureus (bacteria)
KeywordsTRANSCRIPTION / multidrug binding protein / repressor / QacR / cooperative DNA binding

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