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Structure paper

TitleThe anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket
Journal, issue, pagesJ. Biol. Chem., Vol. 279, Page 39824-39828, Year 2004
Publish dateJun 16, 2004 (structure data deposition date)
AuthorsPineda, A.O. / Chen, Z.-W. / Caccia, S. / Cantwell, A.M. / Savvides, S.N. / Waksman, G. / Mathews, F.S. / Di Cera, E.
External linksJ. Biol. Chem. / PubMed:15252033
MethodsX-ray diffraction
Resolution2.4 - 2.8 Å
Structure data

PDB-1tq0:
Crystal structure of the potent anticoagulant thrombin mutant W215A/E217A in free form
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-1tq7:
Crystal structure of the anticoagulant thrombin mutant W215A/E217A bound to PPACK
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-ZN:
Unknown entry

ChemComp-0G6:
D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
KeywordsBLOOD CLOTTING / thrombin / anticoagulant / HYDROLASE/HYDROLASE INHIBITOR / PPACK / HYDROLASE-HYDROLASE INHIBITOR COMPLEX

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