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| Title | N2-Substituted O6-Cyclohexylmethylguanine Derivatives: Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2 |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 47, Page 3710-, Year 2004 |
| Publish date | Jun 10, 2003 (structure data deposition date) |
 Authors | Hardcastle, I.R. / Arris, C.E. / Bentley, J. / Boyle, F.T. / Chen, Y. / Curtin, N.J. / Endicott, J.A. / Gibson, A.E. / Golding, B.T. / Griffin, R.J. ...Hardcastle, I.R. / Arris, C.E. / Bentley, J. / Boyle, F.T. / Chen, Y. / Curtin, N.J. / Endicott, J.A. / Gibson, A.E. / Golding, B.T. / Griffin, R.J. / Jewsbury, P. / Menyerol, J. / Mesguiche, V. / Newell, D.R. / Noble, M.E.M. / Pratt, D.J. / Wang, L.-Z. / Whitfield, H.J. |
 External links | J. Med. Chem. / PubMed:15239650 |
| Methods | X-ray diffraction |
| Resolution | 2 - 2.4 Å |
| Structure data |  PDB-1oi9:  PDB-1oiu:  PDB-1oiy: |
| Chemicals |  ChemComp-N20:  ChemComp-SGM:  ChemComp-MG:  ChemComp-HOH:  ChemComp-N76:  ChemComp-N41: |
| Source |
|
 Keywords | KINASE / TRANSFERASE / SERINE/THREONINE-PROTEIN KINASE / ATP-BINDING / CELL CYCLE / CELL DIVISION / MITOSIS / PHOSPHORYLATION |
homo sapiens (human)