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TitleSynthesis and Antiviral Activity of P1' Arylsulfonamide Azacyclic Urea HIV Protease Inhibitors
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 14, Page 4075-4078, Year 2004
Publish dateMay 10, 2004 (structure data deposition date)
AuthorsHuang, P.P. / Randolph, J.T. / Klein, L.L. / Vasavanonda, S. / Dekhtyar, T. / Stoll, V.S. / Kempf, D.J.
External linksBioorg. Med. Chem. Lett. / PubMed:15225729
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-1t7k:
Crystal Structure of HIV Protease complexed with Arylsulfonamide azacyclic urea
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-BH0:
3-({5-BENZYL-6-HYDROXY-2,4-BIS-(4-HYDROXY-BENZYL)-3-OXO-[1,2,4]-TRIAZEPANE-1-SULFONYL)-BENZONITRILE

ChemComp-HOH:
WATER

Source
  • human immunodeficiency virus 1
KeywordsHYDROLASE / HIV Protease / Arylsulfonamide Azacyclic urea

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