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Structure paper

TitleMechanisms of camptothecin resistance by human topoisomerase I mutations
Journal, issue, pagesJ. Mol. Biol., Vol. 339, Page 773-784, Year 2004
Publish dateDec 8, 2003 (structure data deposition date)
AuthorsChrencik, J.E. / Staker, B.L. / Burgin, A.B. / Pourquier, P. / Pommier, Y. / Stewart, L. / Redinbo, M.R.
External linksJ. Mol. Biol. / PubMed:15165849
MethodsX-ray diffraction
Resolution2.3 - 2.6 Å
Structure data

PDB-1rr8:
Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-1rrj:
Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-TTG:
2-(1-DIMETHYLAMINOMETHYL-2-HYDROXY-8-HYDROXYMETHYL-9-OXO-9,11-DIHYDRO-INDOLIZINO[1,2-B]QUINOLIN-7-YL)-2-HYDROXY-BUTYRIC ACID

ChemComp-TTC:
(S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE / medication, inhibitor*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsISOMERASE/DNA / Protein-DNA complex / Topotecan / Camptothecin / Nucleic Acid / Human Topoisomerase I / ISOMERASE-DNA COMPLEX

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