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TitleStructural Basis for the Deactivation of the Estrogen-related Receptor {gamma} by Diethylstilbestrol or 4-Hydroxytamoxifen and Determinants of Selectivity.
Journal, issue, pagesJ. Biol. Chem., Vol. 279, Page 33639-33646, Year 2004
Publish dateFeb 5, 2004 (structure data deposition date)
AuthorsGreschik, H. / Flaig, R. / Renaud, J.P. / Moras, D.
External linksJ. Biol. Chem. / PubMed:15161930
MethodsX-ray diffraction
Resolution2.13 - 3.2 Å
Structure data

PDB-1s9p:
crystal structure of the ligand-binding domain of the estrogen-related receptor gamma in complex with diethylstilbestrol
Method: X-RAY DIFFRACTION / Resolution: 2.13 Å

PDB-1s9q:
crystal structure of the ligand-binding domain of the estrogen-related receptor gamma in complex with 4-hydroxytamoxifen
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-1tfc:
CRYSTAL STRUCTURE OF THE LIGAND-BINDING DOMAIN OF THE ESTROGEN-RELATED RECEPTOR GAMMA IN COMPLEX WITH A STEROID RECEPTOR COACTIVATOR-1 PEPTIDE
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-1vjb:
crystal structure of the ligand-binding domain of the estrogen-related receptor gamma in complex with 4-hydroxytamoxifen
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

Chemicals

ChemComp-DES:
DIETHYLSTILBESTROL / medication, hormone*YM

ChemComp-HOH:
WATER

ChemComp-OHT:
4-HYDROXYTAMOXIFEN

ChemComp-CHD:
CHOLIC ACID

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsTRANSCRIPTION / ligand-binding domain / antagonist complex / TRANSCRIPTIONALLY ACTIVE CONFORMATION IN ABSENCE OF LIGAND

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