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Structure paper

TitleStructural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase.
Journal, issue, pagesJ. Biol. Chem., Vol. 279, Page 31655-31663, Year 2004
Publish dateApr 28, 2004 (structure data deposition date)
AuthorsMol, C.D. / Dougan, D.R. / Schneider, T.R. / Skene, R.J. / Kraus, M.L. / Scheibe, D.N. / Snell, G.P. / Zou, H. / Sang, B.C. / Wilson, K.P.
External linksJ. Biol. Chem. / PubMed:15123710
MethodsX-ray diffraction
Resolution1.6 - 1.9 Å
Structure data

PDB-1t45:
STRUCTURAL BASIS FOR THE AUTOINHIBITION AND STI-571 INHIBITION OF C-KIT TYROSINE KINASE
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-1t46:
STRUCTURAL BASIS FOR THE AUTOINHIBITION AND STI-571 INHIBITION OF C-KIT TYROSINE KINASE
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-PO4:
PHOSPHATE ION

ChemComp-STI:
4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE / medication, inhibitor*YM

Source
  • homo sapiens (human)
KeywordsTRANSFERASE ACTIVATOR / KINASE / AUTOINHIBITION / INHIBITOR / STI-571 / Gleevec

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