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Structure paper

TitleStructure of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 11, Page 469-474, Year 2004
Publish dateApr 7, 2004 (structure data deposition date)
AuthorsTuske, S. / Sarafianos, S.G. / Clark Jr., A.D. / Ding, J. / Naeger, L.K. / White, K.L. / Miller, M.D. / Gibbs, C.S. / Boyer, P.L. / Clark, P. ...Tuske, S. / Sarafianos, S.G. / Clark Jr., A.D. / Ding, J. / Naeger, L.K. / White, K.L. / Miller, M.D. / Gibbs, C.S. / Boyer, P.L. / Clark, P. / Wang, G. / Gaffney, B.L. / Jones, R.A. / Jerina, D.M. / Hughes, S.H. / Arnold, E.
External linksNat. Struct. Mol. Biol. / PubMed:15107837
MethodsX-ray diffraction
Resolution3 - 3.1 Å
Structure data

PDB-1t03:
HIV-1 reverse transcriptase crosslinked to tenofovir terminated template-primer (complex P)
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

PDB-1t05:
HIV-1 reverse transcriptase crosslinked to template-primer with tenofovir-diphosphate bound as the incoming nucleotide substrate
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-TNV:
[2-(6-AMINO-9H-PURIN-9-YL)-1-METHYLETHOXY]METHYL-TRIPHOSPHATE

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • human immunodeficiency virus 1
  • mus musculus (house mouse)
KeywordsTransferase/Antibody/DNA / HIV-1 RT / tenofovir / RT-DNA complex / Transferase-Antibody-DNA COMPLEX / Transferase/DNA / HIV-1 reverse transcriptase / Transferase-DNA COMPLEX

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