タイトル | A structural and thermodynamic escape mechanism from a drug resistant mutation of the HIV-1 protease. |
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ジャーナル・号・ページ | Proteins, Vol. 55, Page 594-602, Year 2004 |
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掲載日 | 2002年9月18日 (構造データの登録日) |
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著者 | Vega, S. / Kang, L.-W. / Velazquez-Campoy, A. / Kiso, Y. / Amzel, L.M. / Freire, E. |
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リンク | Proteins / PubMed:15103623 |
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手法 | X線回折 |
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解像度 | 2 Å |
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構造データ | PDB-1mrw: Structure of HIV protease (Mutant Q7K L33I L63I) complexed with KNI-577 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-1mrx: Structure of HIV protease (Mutant Q7K L33I L63I V82F I84V ) complexed with KNI-577 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-1msm: The HIV protease (mutant Q7K L33I L63I) complexed with KNI-764 (an inhibitor) 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-1msn: The HIV protease (mutant Q7K L33I L63I V82F I84V) complexed with KNI-764 (an inhibitor) 手法: X-RAY DIFFRACTION / 解像度: 2 Å |
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化合物 | ChemComp-K57: (4R)-N-tert-butyl-3-{(2S,3S)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylbutanoyl}-5,5-dimethyl-1,3-thiazoli / KNI-577
ChemComp-JE2: (4R)-3-{(2S,3S)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylbutanoyl}-5,5-dimethyl-N-(2-methylbenzyl)-1,3-thiazolidine-4-carboxamide / KNI-764
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由来 | ![](img/tx_virus.gif) human immunodeficiency virus 1 (ヒト免疫不全ウイルス)
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キーワード | HYDROLASE/HYDROLASE INHIBITOR / HIV / KNI-577 / protease / drug target / HYDROLASE / HYDROLASE-HYDROLASE INHIBITOR complex / KNI-764 |
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