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Structure paper

TitleStructure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis
Journal, issue, pagesBiochemistry, Vol. 43, Page 4716-4723, Year 2004
Publish dateFeb 3, 2004 (structure data deposition date)
AuthorsGomez, G.A. / Morisseau, C. / Hammock, B.D. / Christianson, D.W.
External linksBiochemistry / PubMed:15096040
MethodsX-ray diffraction
Resolution2.35 - 2.6 Å
Structure data

PDB-1s8o:
Human soluble Epoxide Hydrolase
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-1vj5:
Human soluble Epoxide Hydrolase- N-cyclohexyl-N'-(4-iodophenyl)urea complex
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

Chemicals

ChemComp-P6G:
HEXAETHYLENE GLYCOL / precipitant*YM

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

ChemComp-PO4:
PHOSPHATE ION

ChemComp-CIU:
N-CYCLOHEXYL-N'-(4-IODOPHENYL)UREA

Source
  • homo sapiens (human)
KeywordsHYDROLASE / domain-swapped dimer

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