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Structure paper

TitleAlterations at the Peptidyl Transferase Centre of the Ribosome Induced by the Synergistic Action of the Streptogramins Dalfopristin and Quinupristin.
Journal, issue, pagesBmc Biol., Vol. 2, Page 4-, Year 2004
Publish dateMar 8, 2004 (structure data deposition date)
AuthorsHarms, J.M. / Schlunzen, F. / Fucini, P. / Bartels, H. / Yonath, A.
External linksBmc Biol. / PubMed:15059283
MethodsX-ray diffraction
Resolution3.42 Å
Structure data

PDB-1sm1:
COMPLEX OF THE LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS WITH QUINUPRISTIN AND DALFOPRISTIN
Method: X-RAY DIFFRACTION / Resolution: 3.42 Å

Chemicals

ChemComp-DOL:
5-(2-DIETHYLAMINO-ETHANESULFONYL)-21-HYDROXY-10-ISOPROPYL-11,19-DIMETHYL-9,26-DIOXA-3,15,28-TRIAZA-TRICYCLO[23.2.1.00,255]OCTACOSA-1(27),12,17,19,25(28)-PENTAENE-2,8,14,23-TETRAONE / antibiotic*YM

Source
  • deinococcus radiodurans (radioresistant)
  • streptomyces graminofacien (bacteria)
KeywordsRIBOSOME/ANTIBIOTIC / RIBOSOME-ANTIBIOTIC COMPLEX / QUINUPRISTIN / DALFOPRISTIN / STREPTOGRAMINS / SYNERCID / RIBOSOME / 50S RIBOSOMAL SUBUNIT / RIBOSOM-ANTIBIOTIC COMPLEX

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