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Structure paper

TitleAminomethylpyrimidines as novel DPP-IV inhibitors: a 10(5)-fold activity increase by optimization of aromatic substituents
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 14, Page 1491-1493, Year 2004
Publish dateDec 17, 2003 (structure data deposition date)
AuthorsPeters, J.U. / Weber, S. / Kritter, S. / Weiss, P. / Wallier, A. / Boehringer, M. / Hennig, M. / Kuhn, B. / Loeffler, B.M.
External linksBioorg. Med. Chem. Lett. / PubMed:15006388
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-1rwq:
Human Dipeptidyl peptidase IV in complex with 5-aminomethyl-6-(2,4-dichloro-phenyl)-2-(3,5-dimethoxy-phenyl)-pyrimidin-4-ylamine
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-5AP:
5-(AMINOMETHYL)-6-(2,4-DICHLOROPHENYL)-2-(3,5-DIMETHOXYPHENYL)PYRIMIDIN-4-AMINE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / dipeptidyl peptidase IV / exopeptidase / adenosine binding / drug design / complex structure

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