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TitleStructure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 101, Page 1816-1821, Year 2004
Publish dateDec 18, 2003 (structure data deposition date)
AuthorsFeese, M.D. / Tamada, T. / Kato, Y. / Maeda, Y. / Hirose, M. / Matsukura, Y. / Shigematsu, H. / Muto, T. / Matsumoto, A. / Watarai, H. ...Feese, M.D. / Tamada, T. / Kato, Y. / Maeda, Y. / Hirose, M. / Matsukura, Y. / Shigematsu, H. / Muto, T. / Matsumoto, A. / Watarai, H. / Ogami, K. / Tahara, T. / Kato, T. / Miyazaki, H. / Kuroki, R.
External linksProc. Natl. Acad. Sci. USA / PubMed:14769915
MethodsX-ray diffraction
Resolution2.51 - 3.3 Å
Structure data

PDB-1v7m:
Human Thrombopoietin Functional Domain Complexed To Neutralizing Antibody TN1 Fab
Method: X-RAY DIFFRACTION / Resolution: 2.51 Å

PDB-1v7n:
Human Thrombopoietin Functional Domain Complexed To Neutralizing Antibody TN1 Fab
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM/CYTOKINE / Thrombopoietin / Fab fragment / Complex (Cytokine-Antibody) / IMMUNE SYSTEM-CYTOKINE COMPLEX

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