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TitleThe discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines.
Journal, issue, pagesMOL. CANCER THER., Vol. 3, Page 1-9, Year 2004
Publish dateJul 8, 2003 (structure data deposition date)
AuthorsHamdouchi, C. / Keyser, H. / Collins, E. / Jaramillo, C. / De Diego, J.E. / Spencer, C.D. / Dempsey, J.A. / Anderson, B.D. / Leggett, T. / Stamm, N.B. ...Hamdouchi, C. / Keyser, H. / Collins, E. / Jaramillo, C. / De Diego, J.E. / Spencer, C.D. / Dempsey, J.A. / Anderson, B.D. / Leggett, T. / Stamm, N.B. / Schultz, R.M. / Watkins, S.A. / Cocke, K. / Lemke, S. / Burke, T.F. / Beckmann, R.P. / Dixon, J.T. / Gurganus, T.M. / Rankl, N.B. / Houck, K.A. / Zhang, F. / Vieth, M. / Espinosa, J. / Timm, D.E. / Campbell, R.M. / Patel, B.K. / Brooks, H.B.
External linksPubMed:14749470
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-1pye:
Crystal structure of CDK2 with inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-PM1:
[2-AMINO-6-(2,6-DIFLUORO-BENZOYL)-IMIDAZO[1,2-A]PYRIDIN-3-YL]-PHENYL-METHANONE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / CDK / Cyclin-dependent kinase 2

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