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TitleInositol 1,4,5-trisphosphate receptor contains multiple cavities and L-shaped ligand-binding domains.
Journal, issue, pagesJ Mol Biol, Vol. 336, Issue 1, Page 155-164, Year 2004
Publish dateFeb 6, 2004
AuthorsChikara Sato / Kozo Hamada / Toshihiko Ogura / Atsuo Miyazawa / Kenji Iwasaki / Yoko Hiroaki / Kazutoshi Tani / Akiko Terauchi / Yoshinori Fujiyoshi / Katsuhiko Mikoshiba /
PubMed AbstractCalcium concentrations are strictly regulated in all biological cells, and one of the key molecules responsible for this regulation is the inositol 1,4,5-trisphosphate receptor, which was known to ...Calcium concentrations are strictly regulated in all biological cells, and one of the key molecules responsible for this regulation is the inositol 1,4,5-trisphosphate receptor, which was known to form a homotetrameric Ca(2+) channel in the endoplasmic reticulum. The receptor is involved in neuronal transmission via Ca(2+) signaling and for many other functions that relate to morphological and physiological processes in living organisms. We analysed the three-dimensional structure of the ligand-free form of the receptor based on a single-particle technique using an originally developed electron microscope equipped with a helium-cooled specimen stage and an automatic particle picking system. We propose a model that explains the complex mechanism for the regulation of Ca(2+) release by co-agonists, Ca(2+), inositol 1,4,5-trisphosphate based on the structure of multiple internal cavities and a porous balloon-shaped cytoplasmic domain containing a prominent L-shaped density which was assigned by the X-ray structure of the inositol 1,4,5-trisphosphate binding domain.
External linksJ Mol Biol / PubMed:14741211
MethodsEM (single particle)
Resolution15.0 Å
Structure data

EMDB-1061:
Inositol 1,4,5-trisphosphate receptor contains multiple cavities and L-shaped ligand-binding domains.
Method: EM (single particle) / Resolution: 15.0 Å

Source
  • Mus musculus (house mouse)

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