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Structure paper

TitleCrystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation.
Journal, issue, pagesProtein Sci., Vol. 13, Page 412-421, Year 2004
Publish dateOct 30, 2003 (structure data deposition date)
AuthorsAertgeerts, K. / Ye, S. / Tennant, M.G. / Kraus, M.L. / Rogers, J. / Sang, B.C. / Skene, R.J. / Webb, D.R. / Prasad, G.S.
External linksProtein Sci. / PubMed:14718659
MethodsX-ray diffraction
Resolution2.1 - 2.3 Å
Structure data

PDB-1r9m:
Crystal Structure of Human Dipeptidyl Peptidase IV at 2.1 Ang. Resolution.
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-1r9n:
Crystal Structure of human dipeptidyl peptidase IV in complex with a decapeptide (tNPY) at 2.3 Ang. Resolution
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-FUC:
alpha-L-fucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / aminopeptidase / serine protease / glycoprotein / alpha/beta Hydrolase / Eight-bladed beta propeller

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