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Structure paper

TitleIn vivo activation of the p53 pathway by small-molecule antagonists of MDM2.
Journal, issue, pagesScience, Vol. 303, Page 844-848, Year 2004
Publish dateDec 12, 2003 (structure data deposition date)
AuthorsVassilev, L.T. / Vu, B.T. / Graves, B. / Carvajal, D. / Podlaski, F. / Filipovic, Z. / Kong, N. / Kammlott, U. / Lukacs, C. / Klein, C. ...Vassilev, L.T. / Vu, B.T. / Graves, B. / Carvajal, D. / Podlaski, F. / Filipovic, Z. / Kong, N. / Kammlott, U. / Lukacs, C. / Klein, C. / Fotouhi, N. / Liu, E.A.
External linksScience / PubMed:14704432
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-1rv1:
CRYSTAL STRUCTURE OF HUMAN MDM2 WITH AN IMIDAZOLINE INHIBITOR
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-IMZ:
CIS-[4,5-BIS-(4-BROMOPHENYL)-2-(2-ETHOXY-4-METHOXYPHENYL)-4,5-DIHYDROIMIDAZOL-1-YL]-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]METHANONE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLIGASE / MDM2 / P53 / PROTEIN-PROTEIN INTERACTION

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