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TitleLigand selectivity by seeking hydrophobicity in thyroid hormone receptor.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 100, Page 15358-15363, Year 2003
Publish dateAug 4, 2003 (structure data deposition date)
AuthorsBorngraeber, S. / Budny, M.J. / Chiellini, G. / Cunha-Lima, S.T. / Togashi, M. / Webb, P. / Baxter, J.D. / Scanlan, T.S. / Fletterick, R.J.
External linksProc. Natl. Acad. Sci. USA / PubMed:14673100
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-1q4x:
Crystal Structure of Human Thyroid Hormone Receptor beta LBD in complex with specific agonist GC-24
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-G24:
[4-(3-BENZYL-4-HYDROXYBENZYL)-3,5-DIMETHYLPHENOXY]ACETIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / conformational change in two framework helices upon ligand binding

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