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Structure paper

TitleCrystal structures of phosphodiesterases 4 and 5 in complex with inhibitor IBMX suggest a conformation determinant of inhibitor selectivity
Journal, issue, pagesJ. Biol. Chem., Vol. 279, Page 13095-13101, Year 2004
Publish dateNov 22, 2003 (structure data deposition date)
AuthorsHuai, Q. / Liu, Y. / Francis, S.H. / Corbin, J.D. / Ke, H.
External linksJ. Biol. Chem. / PubMed:14668322
MethodsX-ray diffraction
Resolution2.05 - 2.1 Å
Structure data

PDB-1rkp:
Crystal structure of PDE5A1-IBMX
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

PDB-1zkn:
Structure of PDE4D2-IBMX
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-IBM:
3-ISOBUTYL-1-METHYLXANTHINE / inhibitor, antagonist*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / pde5A / viagra / IBMX / PROTEIN-INHIBITOR COMPLEX / INHIBITOR SELECTIVITY

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