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TitleThe role of lysine 532 in the catalytic mechanism of human topoisomerase I.
Journal, issue, pagesJ. Biol. Chem., Vol. 279, Page 2984-2992, Year 2004
Publish dateOct 3, 2003 (structure data deposition date)
AuthorsInterthal, H. / Quigley, P.M. / Hol, W.G. / Champoux, J.J.
External linksJ. Biol. Chem. / PubMed:14594810
MethodsX-ray diffraction
Resolution3.13 Å
Structure data

PDB-1r49:
Human topoisomerase I (Topo70) double mutant K532R/Y723F
Method: X-RAY DIFFRACTION / Resolution: 3.13 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIsomerase/DNA / Protein / DNA / topoisomerase I / Isomerase-DNA COMPLEX

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