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Structure paper

TitleStructures of {Gamma}-Aminobutyric Acid (Gaba) Aminotransferase, a Pyridoxal 5'-Phosphate, and [2Fe-2S] Cluster-Containing Enzyme, Complexed with {Gamma}-Ethynyl-Gaba and with the Antiepilepsy Drug Vigabatrin
Journal, issue, pagesJ. Biol. Chem., Vol. 279, Page 363-, Year 2004
Publish dateJun 2, 2003 (structure data deposition date)
AuthorsStorici, P. / De Biase, D. / Bossa, F. / Bruno, S. / Mozzarelli, A. / Peneff, C. / Silverman, R. / Schirmer, T.
External linksJ. Biol. Chem. / PubMed:14534310
MethodsX-ray diffraction
Resolution2.3 - 2.8 Å
Structure data

PDB-1ohv:
4-AMINOBUTYRATE-AMINOTRANSFERASE FROM PIG
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-1ohw:
4-AMINOBUTYRATE-AMINOTRANSFERASE inactivated by gamma-vinyl GABA
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-1ohy:
4-AMINOBUTYRATE-AMINOTRANSFERASE inactivated by gamma-ethynyl GABA
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-ACT:
ACETATE ION

ChemComp-PLP:
PYRIDOXAL-5'-PHOSPHATE

ChemComp-FES:
FE2/S2 (INORGANIC) CLUSTER

ChemComp-HOH:
WATER

ChemComp-VIG:
4-AMINO HEXANOIC ACID

ChemComp-GEG:
(4E)-4-AMINOHEX-4-ENOIC ACID

Source
  • sus scrofa (pig)
KeywordsTRANSFERASE / PLP-DEPENDENT ENZYME / AMINOTRANSFERASE / 4- AMINOBUTYRIC ACID / ANTIEPILEPTIC DRUG TARGET / VIGABATRIN PYRIDOXAL PHOSPHATE / NEUROTRANSMITTER DEGRADATION / MITOCHONDRION / TRANSIT PEPTIDE

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