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TitleCrystal Structure of a Superstable Mutant of Human P53 Core Domain. Insights Into the Mechanism of Rescuing Oncogenic Mutations
Journal, issue, pagesJ. Biol. Chem., Vol. 279, Page 1291-, Year 2004
Publish dateSep 19, 2003 (structure data deposition date)
AuthorsJoerger, A.C. / Allen, M.D. / Fersht, A.R.
External linksJ. Biol. Chem. / PubMed:14534297
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-1uol:
Crystal structure of the human p53 core domain mutant M133L/V203A/N239Y/N268D at 1.9 A resolution.
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN / DNA-BINDING PROTEIN / P53 / DNA-BINDING DOMAIN / TUMOR SUPPRESSOR / SECOND-SITE SUPPRESSOR MUTATION / SUPERSTABLE MUTANT / APOPTOSIS / TRANSCRIPTION REGULATION

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