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Structure paper

TitleStructure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 100, Page 10629-10634, Year 2003
Publish dateJun 27, 2003 (structure data deposition date)
AuthorsClassen, S. / Olland, S. / Berger, J.M.
External linksProc. Natl. Acad. Sci. USA / PubMed:12963818
MethodsX-ray diffraction
Resolution1.8 - 1.9 Å
Structure data

PDB-1pvg:
Crystal Structure of the ATPase region of Saccharomyces Cerevisiae topoisomerase II
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-1qzr:
CRYSTAL STRUCTURE OF THE ATPASE REGION OF SACCHAROMYCES CEREVISIAE TOPOISOMERASE II BOUND TO ICRF-187 (DEXRAZOXANE)
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-ANP:
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP, energy-carrying molecule analogue*YM

ChemComp-HOH:
WATER

ChemComp-CDX:
(S)-4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS-2,6-PIPERAZINEDIONE

Source
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsISOMERASE / GHKL ATPase domain / ICRF / ICRF-187 / DEXRAZOXANE

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