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TitleStructural characterization and kinetics of nitric-oxide synthase inhibition by novel N5-(iminoalkyl)- and N5-(iminoalkenyl)-ornithines
Journal, issue, pagesJ. Biol. Chem., Vol. 278, Page 46789-46797, Year 2003
Publish dateSep 4, 2002 (structure data deposition date)
AuthorsBretscher, L.E. / Li, H. / Poulos, T.L. / Griffith, O.W.
External linksJ. Biol. Chem. / PubMed:12960153
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-1mmv:
Rat neuronal NOS heme domain with NG-propyl-L-arginine bound
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-1mmw:
Rat neuronal NOS heme domain with vinyl-L-NIO bound
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-ACT:
ACETATE ION

ChemComp-ZN:
Unknown entry

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-H4B:
5,6,7,8-TETRAHYDROBIOPTERIN / neurotransmitter*YM

ChemComp-3AR:
N-OMEGA-PROPYL-L-ARGININE

ChemComp-HOH:
WATER

ChemComp-VIO:
N5-(1-IMINO-3-BUTENYL)-L-ORNITHINE

Source
  • rattus norvegicus (Norway rat)
KeywordsOXIDOREDUCTASE / nitric oxide synthase / oxydoreductase / heme-enzyme

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