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Structure paper

TitlePotent, Small-Molecule Inhibitors of Human Mast Cell Tryptase. Antiasthmatic Action of a Dipeptide-Based Transition-State Analogue Containing a Benzothiazole Ketone.
Journal, issue, pagesJ. Med. Chem., Vol. 46, Page 3865-3876, Year 2003
Publish dateDec 4, 2002 (structure data deposition date)
AuthorsCostanzo, M.J. / Yabut, S.C. / Almond Jr., H.R. / Andrade-Gordon, P. / Corcoran, T.W. / De Garavilla, L. / Kauffman, J.A. / Abraham, W.M. / Recacha, R. / Chattopadhyay, D. / Maryanoff, B.E.
External linksJ. Med. Chem. / PubMed:12930148
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-1nc6:
Potent, small molecule inhibitors of human mast cell tryptase. Anti-asthmatic action of a dipeptide-based transition state analogue containing benzothiazole ketone
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-ABB:
(2S,4R)-1-ACETYL-N-[(1S)-4-[(AMINOIMINOMETHYL)AMINO]-1-(2-BENZOTHIAZOLYLCARBONYL)BUTYL]-4-HYDROXY-2-PYRROLIDINECARBOXAMIDE

ChemComp-HOH:
WATER

Source
  • bos taurus (domestic cattle)
KeywordsHYDROLASE / protein-inhibitor complex

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