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TitleThe Structural Modifications Induced by the M339F Substitution in PBP2x from Streptococcus pneumoniae Further Decreases the Susceptibility to beta-Lactams of Resistant Strains
Journal, issue, pagesJ. Biol. Chem., Vol. 278, Page 44448-44456, Year 2003
Publish dateJul 9, 2003 (structure data deposition date)
AuthorsChesnel, L. / Pernot, L. / Lemaire, D. / Champelovier, D. / Croize, J. / Dideberg, O. / Vernet, T. / Zapun, A.
External linksJ. Biol. Chem. / PubMed:12923202
MethodsX-ray diffraction
Resolution2.42 Å
Structure data

PDB-1pyy:
Double mutant PBP2x T338A/M339F from Streptococcus pneumoniae strain R6 at 2.4 A resolution
Method: X-RAY DIFFRACTION / Resolution: 2.42 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-HOH:
WATER

Source
  • streptococcus pneumoniae (bacteria)
KeywordsTRANSPEPTIDASE / PENICILLIN-BINDING PROTEIN / ANTIBIOTIC RESISTANCE / PEPTIDOGLYCAN SYNTHESIS / CELL WALL / TRANSMEMBRANE

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