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Structure paper

TitleHuman 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids.
Journal, issue, pagesJ. Mol. Biol., Vol. 331, Page 593-604, Year 2003
Publish dateSep 18, 2002 (structure data deposition date)
AuthorsCouture, J.F. / Legrand, P. / Cantin, L. / Luu-The, V. / Labrie, F. / Breton, R.
External linksJ. Mol. Biol. / PubMed:12899831
MethodsX-ray diffraction
Resolution1.59 Å
Structure data

PDB-1mrq:
Crystal structure of human 20alpha-HSD in ternary complex with NADP and 20alpha-hydroxy-progesterone
Method: X-RAY DIFFRACTION / Resolution: 1.59 Å

Chemicals

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-STR:
PROGESTERONE / hormone*YM

ChemComp-BME:
BETA-MERCAPTOETHANOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / 20alpha-HSD / hydroxysteroid dehydrogenase / progesterone / ternary complex

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