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TitleStructure of Mammalian Cytochrome P450 2C5 Complexed with Diclofenac at 2.1 A Resolution: Evidence for an Induced Fit Model of Substrate Binding
Journal, issue, pagesBiochemistry, Vol. 42, Page 9335-9345, Year 2003
Publish dateJan 23, 2003 (structure data deposition date)
AuthorsWESTER, M.R. / JOHNSON, E.F. / Marques-Soares, C. / Dijols, S. / Dansette, P.M. / Mansuy, D. / STOUT, C.D.
External linksBiochemistry / PubMed:12899620
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-1nr6:
MICROSOMAL CYTOCHROME P450 2C5/3LVDH COMPLEX WITH DICLOFENAC
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-DIF:
2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID / antiinflammatory, medication*YM

ChemComp-HOH:
WATER

Source
  • oryctolagus cuniculus (rabbit)
KeywordsOXIDOREDUCTASE / MEMBRANE PROTEIN / PROGESTERONE 21-HYDROXYLASE / BENZO(A) / PYRENE HYDROXYLASE / ESTRADIOL 2-HYDROXYLASE / P450 / CYP2C5 / DICLOFENAC COMPLEX

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