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Title | Selective Protein Tyrosine Phosphatase 1B Inhibitors: Targeting the Second Phosphotyrosine Binding Site with Non-Carboxylic Acid-Containing Ligands. |
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Journal, issue, pages | J. Med. Chem., Vol. 46, Page 3437-3440, Year 2003 |
Publish date | May 29, 2003 (structure data deposition date) |
![]() | Liu, G. / Xin, Z. / Liang, H. / Abad-Zapatero, C. / Hajduk, P.J. / Janowick, D.A. / Szczepankiewicz, B.G. / Pei, Z. / Hutchins, C.W. / Ballaron, S.J. ...Liu, G. / Xin, Z. / Liang, H. / Abad-Zapatero, C. / Hajduk, P.J. / Janowick, D.A. / Szczepankiewicz, B.G. / Pei, Z. / Hutchins, C.W. / Ballaron, S.J. / Stashko, M.A. / Lubben, T.H. / Berg, C.E. / Rondinone, C.M. / Trevillyan, J.M. / Jirousek, M.R. |
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Methods | X-ray diffraction |
Resolution | 2.2 Å |
Structure data | ![]() PDB-1ph0: |
Chemicals | ![]() ChemComp-418: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE / Protein Tyrosine Phosphatase 1B / oxalyl-aryl-benzoic acid compound inhibitor / salicylic acid moiety at the second site |