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TitleDual Protein Farnesyltransferase-Geranylgeranyltransferase-I Inhibitors as Potential Cancer Chemotherapeutic Agents.
Journal, issue, pagesJ. Med. Chem., Vol. 46, Page 2973-2984, Year 2003
Publish dateOct 7, 2002 (structure data deposition date)
AuthorsDeSolms, S.J. / Ciccarone, T.M. / MacTough, S.C. / Shaw, A.W. / Buser, C.A. / Ellis-Hutchings, M. / Fernandes, C. / Hamilton, K.A. / Huber, H.E. / Kohl, N.E. ...DeSolms, S.J. / Ciccarone, T.M. / MacTough, S.C. / Shaw, A.W. / Buser, C.A. / Ellis-Hutchings, M. / Fernandes, C. / Hamilton, K.A. / Huber, H.E. / Kohl, N.E. / Lobell, R.B. / Robinson, R.G. / Tsou, N.N. / Walsh, E.S. / Graham, S.L. / Beese, L.S. / Taylor, J.S.
External linksJ. Med. Chem. / PubMed:12825937
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-1mzc:
Co-Crystal Structure Of Human Farnesyltransferase With Farnesyldiphosphate and Inhibitor Compound 33a
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-FPP:
FARNESYL DIPHOSPHATE

ChemComp-BNE:
2-[3-(3-ETHYL-1-METHYL-2-OXO-AZEPAN-3-YL)-PHENOXY]-4-[1-AMINO-1-(1-METHYL-1H-IMIDIZOL-5-YL)-ETHYL]-BENZONITRILE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / ALPHA-ALPHA BARREL / INHIBITOR / FTASE / PFTASE / FPP / CAAX / RAS

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