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Structure paper

TitleStructure of human dCK suggests strategies to improve anticancer and antiviral therapy
Journal, issue, pagesNat. Struct. Biol., Vol. 10, Page 513-519, Year 2003
Publish dateApr 28, 2003 (structure data deposition date)
AuthorsSabini, E. / Ort, S. / Monnerjahn, C. / Konrad, M. / Lavie, A.
External linksNat. Struct. Biol. / PubMed:12808445
MethodsX-ray diffraction
Resolution1.6 - 2.21 Å
Structure data

PDB-1p5z:
Structure of human dCK complexed with cytarabine and ADP-MG
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-1p60:
Structure of human dCK complexed with 2'-Deoxycytidine and ADP, Space group C 2 2 21
Method: X-RAY DIFFRACTION / Resolution: 1.96 Å

PDB-1p61:
Structure of human dCK complexed with 2'-Deoxycytidine and ADP, P 43 21 2 space group
Method: X-RAY DIFFRACTION / Resolution: 2.21 Å

PDB-1p62:
Structure of human dCK complexed with gemcitabine and ADP-MG
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-AR3:
CYTARABINE / medication, chemotherapy*YM

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-HOH:
WATER

ChemComp-DCZ:
2'-DEOXYCYTIDINE

ChemComp-GEO:
GEMCITABINE / medication, chemotherapy*YM

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsTRANSFERASE / nucleoside kinase / P-loop / araC / cytarabine / deoxycytidine / gemcitabine

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